5/24/2023 0 Comments Zoster sine herpeteThe specificity of clinical diagnosis in zoster sine herpete is unclear. 9reported that the specificity of clinical diagnosis of zoster (with a rash) is 95% and, therefore, laboratory confirmation is not always required. Therefore, it is not surprising that the immunoglobulin M serologic results were negative in this patient, since the delay in diagnosis resulted in the serologic results not being obtained until approximately 70 days after the onset of his illness. In a study of 25 patients, 21 were positive for VZV immunoglobulin M however, only one patient was still positive 46 days after the illness. 6Sundqvist 8showed that increases in anti-VZV immunoglobulin M, due to zoster, are transient. ![]() Positive anti-VZV immunoglobulin M antibodies are suggestive, but not specific, for herpes zoster. ![]() 6Positive anti-VZV immunoglobulin G antibodies represent previous exposure. Virologic evidence of herpes zoster is difficult to obtain due to a lack of specificity, and because most cases are diagnosed based on clinical features.
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